Thus, NSAID other than aspirin, including selective COX-2 inhibitors, are clearly associated with AKI (8, 38) and should be avoided in people at risk of AKI and stopped if being taken by someone who develops AKI. 2019;69(8): S98-S102. Alexandre P. Zavascki, Roger L. Nation Colistin-induced nephrotoxicity in a tertiary teaching hospital. Pinar N, Ozcan O, Dogan E, Cakirca G. Protective 3. Rosuvastatin: Rosuvastatin is a synthetic lipid lowering agent for oral administration. This study examined the protective effects of vitamin E (VIT. The 14th Scientific International Conference.4. As this trend continues unhindered, we will continue see a persistent rise in obesity-related metabolic effects—hypertension, dyslipidemia, diabetes mellitus, and atherosclerosis. The empirical formula being (C 22 H 27 FN 3 O 6 . Rhabdomyolysis is a serious and potentially life threatening condition that can be caused by drugs. nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine and because renal excretion is the primary elimination route of fibrate drugs including Fenofibrate, there is a risk that . The aim of this study was to analyze the undesirable effects of mild, moderate and high doses of rosuvastatin in CD-1 . Request PDF | Evaluation of the possible nephroprotective effects of vitamin E and rosuvastatin in amikacin-induced renal injury in rats: SELIM et al. 1 Introduction. For this purpose, eight groups of rats were used. Objective To assess the reno-protective effect of rosuvastatin on gentamicin-induced nephrotoxicity in rats. induced nephrotoxicity.20 Nevertheless, rosuvastatin produced insignificant amelioration of serum creatinine and eGFR which might be due to the short duration of the study. However, they do provide some eye-opening information. CIN may be preventable because its risk factors are well established and the timing of renal insult is commonly known in advance. RSV can protect against DN, at least in part, via increasing renal HO-1 expression and/or activity, which seems to be upstream to RSV antioxidant, anti-inflammatory, and anti-apoptotic effects. A single injection of potassium dichromate (15 mg/kg) to rats induced renal tubule damage and an increase in the following markers of renal injury 2 days later; blood urea nitrogen and . In keeping with this, statins (simvastatin, pravastatin and rosuvastatin) inhibited gentamicin accumulation and cytotoxicity in a dose-dependent manner in an in vitro proximal tubule model . These findings informed the design of a phase IIa randomized controlled clinical trial of rosuvastatin for the prevention of aminoglycoside-induced nephrotoxicity in children with CF (The PROteKT study; EudraCT 2014-002387-32, UKCRN ID 16993, ISRCTN26104255). This open label, parallel group, randomised controlled trial recruited children and young people aged 6 to 18 years with CF at 13 paediatric CF treatment centres in the UK. We report a case of acute hepatitis B with rhabdomyolysis after treatment with rosuvastatin and entecavir. effect of dexpanthenol on gentamicin-induced Rosuvastatin Attenuates acute nephrotoxicity through nephrotoxicity in rats. To explore the protective effect and mechanism of rosuvastatin on acute renal injury induced by a nonionic hypotonic contrast medium in rats. Rosuvastatin at 2 different doses showed inc … Rosuvastatin has potent anti-oxidant, free radical scavenging and anti-inflammatory effects. Preapproval clinical trials examining the safety and efficacy of rosuvastatin demonstrated an increased incidence of proteinuria, hematuria, rhabdomyolysis, and other acute kidney injury of unknown cause at high doses. . The aim of this study was to analyze the undesirable effects of mild, moderate and high doses of rosuvastatin in CD-1 . Bardeleben RV, Dunkern T, Kaina B, Fritz G. 2002. e HMG-CoA . Nephrotoxicity Both of these drugs have a narrow range of therapeutic blood concentrations (i.e., below which they lack sufficient efficacy and above which they cause toxicity). Rosuvastatin was the only recent additional prescription, started 14 months earlier at 40 . This was in keeping with the suspected diagnosis of a statin-induced nephrotoxicity. Objectives: This prospective study aimed to explore the effects of various doses of rosuvastatin on the hemodynamic changes, highly sensitive C-reactive protein (hs-CRP) and . The present study was designed to investigate the protective effect of vitamin E and atorvastatin against potassium dichromate-induced nephrotoxicity in rats. Rasheed HA, Al-Kuraishy HM, Al-Gareeb AI. 1-4 In early clinical trials, elevations of aminotransferases were observed in up to 2% of patients. Objectives To estimate the incidence of contrast-induced acute kidney injury (CI-AKI) after intravenous (iv) iodinated contrast material (ICM) exposure. Post-contrast acute kidney injury (PC-AKI) is defined as acute renal impairment within 48 h following exposure to intravascular iodinated contrast agents (ICAs). In rosuvastatin group the peak NGAL values were lower compared with that in control group [(47.60 ± 18.72) μg/L vs (62.19 ± 44.68) μg/L, P = 0.014]. Drug-Induced Nephrotoxicity. 1 Introduction. Rosuvastatin was the only recent additional prescription, started 14 months earlier at 40 . Mostafa RE, Dalia OS, Dina FM. 2008 Sep 15 . DOI: 10.7324/JAPS.2018.8406. Rosuvastatin attenuates acute nephrotoxicity through modulation of oxidative stress in Sprague Dawley rats J Pak Med Assoc , 69 ( Suppl. For this purpose, eight groups of rats were used. The latter cases manifested with urine sediment findings and in some cases, renal histology, indicating renal tubular injury in the absence of rhabdomyolysis. nephrotoxicity in rats. Aspirin inhibits prostaglandin synthesis through a mechanism similar to NSAID and COX-2 inhibitors. There are several risk factors for CIN, but patients with pre . S98 - s102 View Record in Scopus Google Scholar J Pak Med Assoc. The Planet 1 and 2 studies are not widely publicized. Among older adults, the incidence of drug-induced nephrotoxicity may be as high as 66 percent.". The rosuvastatin Cmax and AUC0−∞ in rat plasma increased 55% and 61%, respectively in the combination treatment group; and the liver scutellarin concentrations decreased 32%, 34%, and 33% at 1 . Contrast-induced nephrotoxicity (CIN) is a form of acute kidney injury that follows intravascular contrast media exposure. To overcome these drawbacks the present study aimed to formulate transdermal patch of Rosuvastatin calcium. The aim of study was to evaluate the effect of commonly used lisinopril, rosuvastatin and their combined action on site-specific nephrotoxicity in rats using clusterin and microalbumin nephrotoxic . Quercetin and rosuvastatin groups (4:8) showed signs of restored ovarian function in the form of a significant, dose-dependent increase in primordial follicles number, serum anti-Mullerian hormone level, and ovarian tissue glutathione level (p < 0.05) versus group 3, and a significant, dose-dependent decrease in atretic follicles number and ovarian tissue level of malondialdehyde (p < 0.05 . Methods The prospective experimental study was conducted at the College of Medicine, Mustansiriya University, Baghdad, Iraq, from March to July, 2018, and comprised Sprague Dawley male rats aged 3-4 months and weighing 200-400g each. The PROteKT study tested the hypothesis that rosuvastatin can inhibit aminoglycoside-induced nephrotoxicity in children with Cystic Fibrosis (CF). The aim of study was to evaluate the effect of commonly used lisinopril, rosuvastatin and their combined action on site-specific nephrotoxicity in rats using clusterin and microalbumin nephrotoxic biomarkers and other related parameters using oral gavage. We felt that rosuvastatin was the most promising candidate based upon its pharmacology. Am Fam Physician. Like remaining statins Rosuvastatin-calcium is also a poorly soluble drug and not exceeding 20% of bioavailability due to first pass metabolism. Aspirin is an importance exception. The . | Amikacin (AMIK) is an aminoglycoside . The aim of study was to evaluate the effect of commonly used lisinopril, rosuvastatin and their combined action on site-specific nephrotoxicity in rats using clusterin and microalbumin nephrotoxic biomarkers and other related parameters using oral gavage. 1-4 In early clinical trials, elevations of aminotransferases were observed in up to 2% of patients. S-98 The 14th Scientific International Conference ANIMAL RESEARCH Rosuvastatin Attenuates acute nephrotoxicity through modulation of oxidative stress in Sprague Dawley rats Huda Abdulbaki Rasheed, Hayder M. Al-kuraishy, Ali I. Al-Gareeb Abstract Objectives: To assess the reno-protective effect of rosuvastatin on gentamicin-induced nephrotoxicity in rats. This study examined the protective effects of vitamin E (VIT. Rosuvastatin Attenuates acute nephrotoxicity through modulation of oxidative stress in Sprague Dawley rats. A 72-year-old female was admitted to our hospital due to acute hepatitis B infection. Gentamycin infusion markedly reduced kidney . . Diabetic rats were then divided into five groups: 1 diabetic rats (D), 2 diabetic rats + contrast media (DCM), 3 diabetic rats + rosuvastatin (DR), 4 diabetic rats + contrast media + rosuvastatin (DRCM), 5 non-diabetic rat . 3 ) ( 2019 ) , pp. Rosuvastatin at 2 different doses showed increase in urinary microalbumin levels whereas lisinopril and its combination with There is indeed additional recent literature suggesting acute nephrotoxicity associated with high-potency statins, 22,23 with one case report of suspected direct tubular toxicity associated with high-dose rosuvastatin. Received, July 1, 2013; revised, September 27, 2013; accepted, September 29 . However, rosuvastatin is a substrate of BCRP and this transporter limits absorption of rosuvastatin across the gastrointestinal tract (Elsby et al ., 2012; Clin Pharmacol Ther 92:584-598). . Three months later, serum creatinine level was 1.06 . 2018;8(4):43-50. The prevalence of obesity in the United States remains high, exceeding 30% in most states. This open label, parallel group, randomised controlled trial recruited children and young people aged 6 to 18 years with CF at 13 paediatric CF treatment … She had taken atorvastatin for 3 months before being admitted to our hospital. " Crestor (rosuvastatin) for High Cholesterol: I have taken 10mg of Crestor for 3 yrs. 15. It also helps to reduce risk of f . Xueli Zhang. Contrast-induced nephrotoxicity (CIN) is a form of acute kidney injury that follows intravascular contrast media exposure. Druginformer Identified Side Effects: Bone pain, Myalgia, Depression, Mood altered, Muscle atrophy, Adverse drug reaction, Bone loss, Blood test. Amikacin (AMIK) is an aminoglycoside antibiotic that possesses considerable nephrotoxic adverse effects. Al-Kuraishy HM, Al-Gareeb AI, Al-Naimi MS. Renoprotective effect of irbesartan in a rat model of gentamicin-induced nephrotoxicity: Role of oxidative . However, contrast-induced nephrotoxicity is still the third leading cause of iatrogenic renal failure. Saudi Journal of Kidney Disease and Transplantation ,2020, vol 31 (5): 1057-1061 Rosuvastatin calcium is an antilipemic agent that competitively inhibits hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. Statins are the cornerstone of therapy for individuals with hyperlipidemia. Amikacin (AMIK) is an aminoglycoside antibiotic that possesses considerable nephrotoxic adverse effects. The aim of study was to evaluate the effect of commonly used lisinopril, rosuvastatin and their combined action on site-specific nephrotoxicity in rats using clusterin and microalbumin nephrotoxic . Background Rosuvastatin has been shown to provide effective treatment of dyslipidaemia in patients with end-stage renal disease (ESRD) undergoing haemodialysis, but data from controlled trials are very limited on the pharmacokinetics and pharmacodynamics of rosuvastatin in this population. nephrotoxicity in rats using clusterin and microalbumin nephrotoxic biomarkers and other related parameters using oral gavage. Methods This prospective cohort study included all consecutive patients who underwent radiological investigations using low-osmolar iopamidol 370 mg/ml in a regional hospital over a period of 36 months, without any exclusion criteria. The current study investigates the possible mechanisms responsible for the nephro-protective effects of simvastatin (SIM) and rosuvastatin (RST) in cisplatin-induced nephrotoxicity in rats. statin-induced nephrotoxicity.Threemonths later,serum creatinine level was 1.06 mg/dL (eGFR, 69 mL/min/1.73 m2) and urinalysis nephropathy and rosuvastatin nephrotoxicity. Posted By georgephipps in drugs.com on December 7, 2010 @ 12:00 am. No differences of the peak values of SCr were found between the two groups. Three months later, serum creatinine level was 1.06 . Objective: To assess the reno-protective effect of rosuvastatin on gentamicin-induced nephrotoxicity in rats. Two control groups r … 1-4 Despite this clinically apparent liver injury was very rarely observed in the . Biol Pharm Bull 76. Lowered total cholesterol from 2. Objective . Atorvastatin and rosuvastatin are drugs with high cholesterol-lowering efficacy as compared with lovastatin, simvastatin, pravastatin, and fluvastatin, which have less cholesterol-lowering potency. J Pharm Pharm Sci (www.cspsCanada.org) 16(4) 588 - 608, 2013 588 Statins Against Drug-Induced Nephrotoxicity Simin Dashti-Khavidaki1,2, Azadeh Moghaddas1, Behrooz Heydari1, Hossein Khalili1, Mahboob Lessan-Pezeshki2 1Faculty of Pharmacy, 2Nephrology Research Center, Tehran University of Medical Sciences, Tehran, Iran. ". The causative drug must be identified and its use must be . 10 One of the 9 patients involved . Statins are among the most commonly used type of drugs worldwide in patients with hypercholesterolaemia and other risk factors for cardiovascular disease, both in primary and secondary prevention. T oxicology 274:18-26. The rosuvastatin doses chosen for this study are based on the lowest and highest doses applied in human therapy for children (Leite et al., 2018a, Leite et al., 2019b, Leite et al., 2018c), adapted for rodents considering their body surface area, as proposed for Reagan-Shaw et al. Background and Objectives: Nephroprotective effect of statins is still controversial. Methods: The prospective experimental study was conducted at the College of Medicine, Mustansiriya University, Baghdad, Iraq, from March to July, 2018, and comprised Sprague Dawley male rats aged 3-4 months and weighing 200-400g each. The aim of study was to evaluate the effect of commonly used lisinopril, rosuvastatin and their combined action on site-specific nephrotoxicity in rats using clusterin and microalbumin nephrotoxic biomarkers and other related parameters using oral gavage. Contrast-induced nephropathy (CIN) is an important cause of acute renal failure. Rosuvastatin has been shown to activate PI3K/Akt/Nrf2/HO‐1 pathway, which . *— To avoid nephrotoxicity it is recommended that the patient have a daily urine output of 1 mL for every 1.3 mg of acyclovir administered. Salama AAA, Mostafa RE, Omara EA. This is the first randomised controlled trial in man to assess whether rosuvastatin has a protective effect against tobramycin-induced nephrotoxicity. Academia.edu is a platform for academics to share research papers. Bader Z, Waheed A, Bakhtiar S, Khan IM (2018) Alpha-tocopherol ameliorates nephrotoxicity associated with the use of colistin in rabbits. Rosuvastatin (Crestor) 5 to 40 mg daily. Methods . These diseases are also the leading causes of chronic kidney diseases and end-stage renal disease. Rosuvastatin and Fenofibrate Tablets IP 10mg/160mg (Rosutaj-F) Taj Pharma Overview INTRODUCTION Rosutaj-F 160mg/5mg Tablet is a medicine used to treat high cholesterol. Methods Sprague Dawley rats, (n=4/group) received in-traperitoneal (IP) dosing with saline (control), gentamicin (200 mg/kg/day), rosuvastatin (40 mg/kg/day), or gentami-cin and rosuvastatin for 9 days. This is a combination medicine that reduces "bad" cholesterol (LDL) and triglycerides (fats) levels. D A Al-Abdulkarim, O A Alzuwayed, M Al Ammari et al. The PROteKT study tested the hypothesis that rosuvastatin can inhibit aminoglycoside-induced nephrotoxicity in children with Cystic Fibrosis (CF). The anti-inflammatory effect of rosuvastatin was well revealed E) or rosuvastatin (ROSU) against AMIK-induced nephrotoxicity. nephrotoxicity in rats using clusterin and microalbumin nephrotoxic biomarkers and other related parameters using oral gavage. Forty-eight healthy adult SD rats were randomly divided into three groups: normal control group (NC); contrast medium control group (CM); and rosuvastatin intervention group (RI). CYNTHIA A. NAUGHTON, PharmD, BCPS, North Dakota State University College of Pharmacy, Nursing, and Allied Sciences, Fargo, North Dakota. Contrast-induced nephropathy (CIN) is an iatrogenic disorder caused by renal degeneration due to ICA exposure. The contribution of insulin muscle resistance to the development of type 2 diabetes mellitus is significant, which probably explains the results that the Materials and methods: Adult female Wistar rats were divided into six groups: control group (Group 1) received 0.5% sodium carboxy methyl cellulose, group 2 and group 3 received SIM and RST for 10 days, respectively, and group 4 was injected . Rosuvastatin at 2 different doses showed increase in urinary microalbumin levels whereas lisinopril and its combination with The aim of this study was to investigate the possible hemin-like nephroprotective effect of rosuvastatin (RSV) in . The lipid nephrotoxicity . 2 Urine clusterin levels also were raised significantly in the presence of high dose of lisinopril (50 mg/kg . Published studies in rat models of aminoglycoside-induced nephrotoxicity have consistently demonstrated a protective effect with a range of statins, including atorvastatin 17 - 19, simvastatin 15, 16 and rosuvastatin 20. Rosuvastatin is orally administered and, therefore, intestinal absorption is required before the drug reaches the systemic circulation. Nephrotoxicity was measured using urinary N-Acetyl-β-d-glucosaminidase (NAG) and kidney injury molecule-1 (kim-1) on urine samples collected within 24 hours after the final dose. According to a 2008 review published in American Family Physician: "Drugs cause approximately 20 percent of community-and hospital-acquired episodes of acute renal failure. We observe the effect of rosuvastatin on preventing CIN in diabetic rats in current study. Drug-induced nephrotoxicity is caused by nephrotoxic drugs or toxins which damage kidneys and can lead to nephritis or renal toxicity. The aim of study was to evaluate the effect of commonly used lisinopril, rosuvastatin and their combined action on site-specific nephrotoxicity in rats using clusterin and microalbumin nephrotoxic biomarkers and other related parameters using oral gavage. . Selim A, Khalaf MM, Gad AM, Abd El-Raouf OM (2017) Evaluation of the possible nephroprotective effects of vitamin E and rosuvastatin in amikacin-induced renal injury in rats. Rosuvastatin (Crestor) 5 to 40 mg daily. *— To avoid nephrotoxicity it is recommended that the patient have a daily urine output of 1 mL for every 1.3 mg of acyclovir administered. Ozbek et al. The register also displays information on 18700 older paediatric trials (in scope of Article 45 of the Paediatric Regulation (EC) No 1901/2006). Statins are the cornerstone of therapy for individuals with hyperlipidemia. The EU Clinical Trials Register currently displays 41830 clinical trials with a EudraCT protocol, of which 6880 are clinical trials conducted with subjects less than 18 years old. According to these studies, in patients with diabetes and intact renal function, there was a significant decline in renal function and failure to reduce urinary protein in patients randomized to rosuvastatin but not atorvastatin. CIN may be preventable because its risk factors are well established and the timing of renal insult is commonly known in advance. 1-4 Despite this clinically apparent liver injury was very rarely observed in the . This was in keeping with the suspected diagnosis of a statin-induced nephrotoxicity. In part, drugs can cause kidney inflammation, which can lead to fibrosis . 22 Pak J Pharm Sci 31: 463-467. studied the effect of atorvastatin on gentamicin-induced nephrotoxicity in rats. Statins are among the most commonly used type of drugs worldwide in patients with hypercholesterolaemia and other risk factors for cardiovascular disease, both in primary and secondary prevention. Cisplatin use as a chemotherapeutic agent is restricted due to its nephrotoxicity. Cisplatin-induced nephrotoxicity in rats: modulatory role of simvastatin and rosuvastatin against apoptosis and inflammation. Acute nephrotoxicity was induced in rats by single injection of cisplatin (Reagan‐Shaw et al., 2008).To investigate the effects of rosuvastatin exposure on female reproductive function . Nephrotoxicity of polymyxins: Is there any difference between colistimethate and polymyxin B? Evaluation of the Effect of Rosuvastatin on Cisplatin-induced Nephrotoxicity and Ototoxicity The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. J Appl Pharm Sci. Food and Drug Administration (FDA) recommended nephrotoxicity biomarker clusterin and its site-specific role in predicting kidney toxicity of proximal tubule and distal tubule is useful to assess early and site-specific renal toxicity. Objective The aim of the present study was to better define the pharmacokinetic and pharmacodynamic . E) or rosuvastatin (ROSU) against AMIK-induced nephrotoxicity. . Objectives: This study aimed to investigate the protective effect of simvastatin (SIM) and rosuvastatin (RST) on cisplatin (CIS)-induced nephrotoxicity. rosuvastatin use inclinicalpracticedemonstrated thatit was more likely to be associated with a composite kid-ney adverse end point of rhabdomyolysis, proteinuria, . Cyclosporine with grapefruit juice (single serving of 250 mL) produced a mean oral bioavailability that was 162% of that with water. Also were raised significantly in the presence of high dose of lisinopril ( 50 mg/kg iatrogenic failure! Zavascki, Roger L. 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O a Alzuwayed, M Al Ammari et Al is still the third leading cause iatrogenic! Xueli Zhang 40 mg daily on acute renal injury induced by a nonionic hypotonic contrast medium in rats (. May be preventable because its risk factors for CIN, but patients with kidney.
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